THE IMPACT OF ANIONIC POLYMERS ON GENE DELIVERY: HOW COMPOSITION AND ASSEMBLY HELP EVADING THE TOXICITY-EFFICIENCY DILEMMA

The impact of anionic polymers on gene delivery: how composition and assembly help evading the toxicity-efficiency dilemma

Abstract Cationic polymers have been widely studied for non-viral gene vetality twist and lick delivery due to their ability to bind genetic material and to interact with cellular membranes.However, their charged nature carries the risk of increased cytotoxicity and interaction with serum proteins, limiting their potential in vivo application.There

read more

The Pituitary-Adrenal Response to Paradoxical Sleep Deprivation Is Similar to a Psychological Stressor, Whereas the Hypothalamic Response Is Unique

Stressors of different natures induce activation of the hypothalamic-pituitary-adrenal (HPA) axis at different magnitudes.Moreover, the HPA axis response to repeated exposure is usually distinct from that elicited by a single session.Paradoxical sleep deprivation (PSD) augments ACTH and corticosterone (CORT) levels, but the nature of this stimulus

read more